Identification and characterization of a mosquito-specific eggshell organizing factor in Aedes aegypti mosquitoes.

ABSTRACT: Mosquito-borne diseases are responsible for several million human deaths annually around the world. One approach to controlling mosquito populations is to disrupt molecular processes or antagonize novel metabolic targets required for the production of viable eggs. To this end, we focused our efforts on identifying proteins required for completion of embryonic development that are mosquito selective and represent potential targets for vector control. We performed bioinformatic analyses to identify putative protein-coding sequences that are specific to mosquito genomes. Systematic RNA interference (RNAi) screening of 40 mosquito-specific genes was performed by injecting double-stranded RNA (dsRNA) into female Aedes aegypti mosquitoes. This experimental approach led to the identification of e

SUBMITTER: Isoe J 

PROVIDER: S-EPMC6324781 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature