Gene expression variation and parental allele inheritance in a Xiphophorus interspecies hybridization model.

ABSTRACT: Understanding the genetic mechanisms underlying segregation of phenotypic variation through successive generations is important for understanding physiological changes and disease risk. Tracing the etiology of variation in gene expression enables identification of genetic interactions, and may uncover molecular mechanisms leading to the phenotypic expression of a trait, especially when utilizing model organisms that have well-defined genetic lineages. There are a plethora of studies that describe relationships between gene expression and genotype, however, the idea that global variations in gene expression are also controlled by genotype remains novel. Despite the identification of loci that control gene expression variation, the global understanding of how genome constitution affects trai

SUBMITTER: Lu Y 

PROVIDER: S-EPMC6324826 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature