Arid3a regulates nephric tubule regeneration via evolutionarily conserved regeneration signal-response enhancers.

ABSTRACT: Amphibians and fish have the ability to regenerate numerous tissues, whereas mammals have a limited regenerative capacity. Despite numerous developmental genes becoming reactivated during regeneration, an extensive analysis is yet to be performed on whether highly regenerative animals utilize unique cis-regulatory elements for the reactivation of genes during regeneration and how such cis-regulatory elements become activated. Here, we screened regeneration signal-response enhancers at the lhx1 locus using Xenopus and found that the noncoding elements conserved from fish to human function as enhancers in the regenerating nephric tubules. A DNA-binding motif of Arid3a, a component of H3K9me3 demethylases, was commonly found in RSREs. Arid3a binds to RSREs and redu

SUBMITTER: Suzuki N 

PROVIDER: S-EPMC6324879 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature