The role of coronary artery calcification testing in incident coronary artery disease risk prediction in type 1 diabetes.

ABSTRACT:

Aims/hypothesis

We sought to assess the role of coronary artery calcification (CAC) and its progression in predicting incident coronary artery disease (CAD) in individuals with type 1 diabetes using data from the Pittsburgh Epidemiology of Diabetes Complications (EDC) Study.

Methods

The present study examined 292 participants who had at least one CAC measure and were free from CAD at baseline; 181 (62%) had repeat CAC assessments 4-8 years later and did not develop CAD between the two CAC measures. The HRs of incident CAD events were estimated using Cox models in categorised or in appropriately transformed CAC scores. C statistics and net reclassification improvement (NRI) were used to assess the added predictive value of CAC for incident CAD.

Results

At baseline, the

SUBMITTER: Guo J 

PROVIDER: S-EPMC6324941 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature