Identification of Serum Biomarker Panels for the Early Detection of Pancreatic Cancer.

ABSTRACT:

Background

Pancreatic cancer is a deadly disease for which available biomarkers, such as CA19-9, lack the desired sensitivity and specificity for early detection. Additional biomarkers are needed to improve both its sensitivity and specificity.

Methods

Multiplex immunoassays were developed for selected biomarkers using a Bio-Plex 200 system, and analytical performance was optimized. All proteins were analyzed in sera of patients diagnosed with pancreatic ductal adenocarcinoma (PDAC; n = 188) or benign pancreatic conditions (131) and healthy controls (89). The clinical performance of these markers was evaluated individually or in combination for their ability to complement CA19-9 for the early detection of pancreatic cancer.

Results

A 6-plex immunoassay was deve

SUBMITTER: Song J 

PROVIDER: S-EPMC6324978 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature