Modified capture-recapture estimates of the number of families with Lynch syndrome in Central Ohio.

ABSTRACT: Past methods for estimating the population frequency of familial cancer syndromes have used cases and controls ignoring the familial nature of genetic disease. In this study we modified the capture-recapture method from ecology to estimate the number of families in central Ohio with Lynch syndrome (LS). We screened 1566 colorectal cancer cases and 545 endometrial cancer cases in central Ohio from 1999 to 2005 and identified 58 with LS. We screened an additional 3346 colorectal and 342 endometrial cancer cases from 2013 to 2016 and identified 149 with LS. We found 12 LS mutations shared between families observed in the first and second studies. We identified three individuals between studies who were closely related and eight who were more distantly related. We used identified family relati

SUBMITTER: Ranola JMO 

PROVIDER: S-EPMC6324998 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature