Microglia Regulate Neuroglia Remodeling in Various Ocular and Retinal Injuries.

ABSTRACT: Reactive microglia and infiltrating peripheral monocytes have been implicated in many neurodegenerative diseases of the retina and CNS. However, their specific contribution in retinal degeneration remains unclear. We recently showed that peripheral monocytes that infiltrate the retina after ocular injury in mice become permanently engrafted into the tissue, establishing a proinflammatory phenotype that promotes neurodegeneration. In this study, we show that microglia regulate the process of neuroglia remodeling during ocular injury, and their depletion results in marked upregulation of inflammatory markers, such as Il17f, Tnfsf11, Ccl4, Il1a, Ccr2, Il4, Il5, and Csf2 in the retina, and abnormal engraftment of peripheral CCR2⁺ CX3CR1⁺ monocytes int

SUBMITTER: Paschalis EI 

PROVIDER: S-EPMC6325007 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature