Atypical longitudinal development of functional connectivity in adolescents with autism spectrum disorder.

ABSTRACT: Autism spectrum disorder (ASD) is consistently associated with alterations in brain connectivity, but there are conflicting results as to where and when individuals with ASD display increased or reduced functional connectivity. Such inconsistent findings may be driven by atypical neurodevelopmental trajectories in ASD during adolescence, but no longitudinal studies to date have investigated this hypothesis. We thus examined the functional connectivity of three neurocognitive resting-state networks-the default mode network (DMN), salience network, and central executive network (CEN)-in a longitudinal sample of youth with ASD (n = 16) and without ASD (n = 22) studied during early/mid- and late adolescence. Functional connectivity between the CEN and the DMN displayed significantly altered de

SUBMITTER: Lawrence KE 

PROVIDER: S-EPMC6325013 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature