Relationship between Circulating Inflammation Proteins and Lung Cancer Diagnosis in the National Lung Screening Trial.

ABSTRACT:

Background

Previously, we observed a strong relationship between circulating serum inflammation proteins in relation to lung cancer diagnosis and risk, both in case-control and prospective cohorts. Low-dose computed tomography (LDCT) screening has a high prevalence of false-positive nodules, thus companion noninvasive biomarkers that can distinguish between benign and malignant nodules could have clinical utility and positive impact on patient outcomes.

Methods

We conducted a nested case-control study within the National Lung Screening Trial. Concentrations of 30 inflammation proteins were measured on plasma samples of 262 cases and 528 controls using a highly sensitive and analytically validated electrochemiluminescence V-PLEX immunoassay.

Results

Comparing the fourt

SUBMITTER: Brown D 

PROVIDER: S-EPMC6325020 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature