Time-related changes in hepatic and colonic mitochondrial oxygen consumption after abdominal infection in rats.

ABSTRACT:

Background

Evidence suggests that early adaptive responses of hepatic mitochondria occur in experimentally induced sepsis. Little is known about both colonic mitochondrial function during abdominal infection and long-term changes in mitochondrial function under inflammatory conditions. We hypothesize that hepatic and colonic mitochondrial oxygen consumption changes time-dependently after sterile laparotomy and in the course of abdominal infection. The aim of the present study was to investigate the hepatic and colonic mitochondrial respiration after sterile laparotomy and abdominal infection over up to 96 h.

Methods

After approval of the local Animal Care and Use Committee, 95 Wistar rats were randomized into 8 groups (n = 11-12): 1-4 sham (laparotomy only) and 5-8 colon asc

SUBMITTER: Herminghaus A 

PROVIDER: S-EPMC6325055 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature