On chaotic dynamics in transcription factors and the associated effects in differential gene regulation.

ABSTRACT: The control of proteins by a transcription factor with periodically varying concentration exhibits intriguing dynamical behaviour. Even though it is accepted that transcription factors vary their dynamics in response to different situations, insight into how this affects downstream genes is lacking. Here, we investigate how oscillations and chaotic dynamics in the transcription factor NF-κB can affect downstream protein production. We describe how it is possible to control the effective dynamics of the transcription factor by stimulating it with an oscillating ligand. We find that chaotic dynamics modulates gene expression and up-regulates certain families of low-affinity genes, even in the presence of extrinsic and intrinsic noise. Furthermore, this leads to an increase in the production

SUBMITTER: Heltberg ML 

PROVIDER: S-EPMC6325146 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature