OXA-48-Like-Producing Klebsiella pneumoniae in Southern Spain in 2014-2015.

ABSTRACT: The aim of this study was to characterize the population structure of 56 OXA-48-like-producing Klebsiella pneumoniae isolates, as well as extended-spectrum β-lactamase (ESBL) and carbapenemase genes, recovered in 2014 and 2015 from 16 hospitals in southern Spain. XbaI pulsed-field gel electrophoresis and multilocus sequence typing were performed to assess clonal relatedness. Representative isolates belonging to OXA-48-like-producing and CTX-M-15-coproducing pulsotypes were selected for characterization of bla_OXA-48-like- and bla_CTX-M-15-carrying plasmids by PCR-based replicon typing, IncF subtyping, whole-genome sequencing analysis, and typing of Tn1999 structures. Forty-three OXA-48-producing isolates (77%) were recovered from clinical sam

SUBMITTER: Machuca J 

PROVIDER: S-EPMC6325174 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature