Burden and impact of multifactorial geriatric syndromes in allogeneic hematopoietic cell transplantation for older adults.

ABSTRACT: Multifactorial geriatric syndromes are highly prevalent in older patients with cancer. Because an increasing number of older patients undergo allogeneic hematopoietic stem cell transplantation (allo-HCT), we examined the incidence and impact of transplant-related geriatric syndromes using our institutional database and electronic medical records. We identified 527 patients age 60 years or older who had undergone first allo-HCT from 2001 to 2016 for hematologic malignancies. From the initiation of conditioning to 100 days posttransplant, new geriatric syndromes were predominantly delirium with a cumulative incidence of 21% (95% confidence interval [CI], 18%-25%) at day 100 followed by fall at 7% (95% CI, 5%-9%). In multivariable analyses of available pretransplant variables, fall within the

SUBMITTER: Lin RJ 

PROVIDER: S-EPMC6325300 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature