H₂S promotes proliferation of endometrial stromal cells via activating the NF-κB pathway in endometriosis.

ABSTRACT: Hydrogen sulfide (H₂S) is substantially converted from cysteine by the enzymes cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE). H₂S can profoundly affect most organ systems in animals and humans by inducing a wide range of physiological functions. However, the roles of H₂S in the progression of endometriosis remain unknown. The aim of the current study was to test the hypothesis that H₂S might play a role in the pathogenesis of endometriosis via modulating the biological behavior of endometrial stromal cells (ESCs). First, we explored the expression level of CBS and CSE in ESCs via immunohistochemistry and immunocytochemistry. Second, cell Count Kit-8 (CCK-8) assays were utilized to investigate the cell viability of human ESCs (HES

SUBMITTER: Lei S 

PROVIDER: S-EPMC6325523 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature