Genetic polymorphisms of estrogen receptor genes are associated with breast cancer susceptibility in Chinese women.

ABSTRACT:

Background

Estrogen exposure is a widely known risk factor for BC. And the interaction of estrogen with estrogen receptor (ER) plays an important role in breast cancer development. This case-control study aims to assess the association of genetic polymorphisms in the estrogen receptor genes with breast cancer (BC) susceptibility in Chinese Han women.

Methods

Four polymorphisms (rs2881766, rs9383951, rs9340799 in ESR1 and rs3020449 in ESR2) were genotyped in 459 patients and 549 healthy controls using the Sequenom MassARRAY method. Odds ratio (OR) and 95% confidence intervals (95% CI) were calculated to evaluate the associations. False-positive report probability (FPRP) was utilized to examine the noteworthiness of significant findings.

Results

We observe

SUBMITTER: Dai Z 

PROVIDER: S-EPMC6325673 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature