Cluster expansion of apolipoprotein D (ApoD) genes in teleost fishes.

ABSTRACT:

Background

Gene and genome duplication play important roles in the evolution of gene function. Compared to individual duplicated genes, gene clusters attract particular attention considering their frequent associations with innovation and adaptation. Here, we report for the first time the expansion of the apolipoprotein D (ApoD) ligand-transporter genes in a cluster manner specific to teleost fishes.

Results

Based on comparative genomic and transcriptomic analyses, protein 3D structure comparison, positive selection detection and breakpoints detection, the single ApoD gene in the ancestor expanded into two clusters following a dynamic evolutionary pattern in teleost fishes. Orthologous genes show conserved expression patterns, whereas lineage-specific duplicated genes show t

SUBMITTER: Gu L 

PROVIDER: S-EPMC6325677 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature