Dynamics expression of DmFKBP12/Calstabin during embryonic early development of Drosophila melanogaster.

ABSTRACT:

Background

Calcium signaling are conserved from invertebrates to vertebrates and plays critical roles in many molecular mechanisms of embryogenesis and postnatal development. As a critical component of the signaling pathway, the RyR medicated calcium-induced calcium release signaling system, has been well studied along with their regulator FK506-binding protein 12 (FKBP12/Calstabin). Lack of FKBP12 is known to result in lethal cardiac dysfunction in mouse. However, precisely how FKBP12 is regulated and effects calcium signaling in Drosophila melanogaster remains largely unknown.

Results

In this study, we identified both temporal and localization changes in expression of DmFKBP12, a translational and transcriptional regulator of Drosophila RyR (DmRyR) and

SUBMITTER: Feng R 

PROVIDER: S-EPMC6325743 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature