Single nucleotide polymorphism in the 3' untranslated region of LPP is a risk factor for lung cancer: a case-control study.

ABSTRACT:

Background

Single nucleotide polymorphisms (SNPs) in 3'-untranslated region (UTR) of genes related with cell-matrix adhesions and migration might affect miRNA binding and potentially affect the risk of cancer. The present study aimed to screen SNPs in 3' UTR of cancer-related genes and investigate their contribution to the susceptibility of lung cancer.

Methods

Seven SNPs were selected and genotyped in a case-control study (322 lung cancer patients and 384 controls) among Chinese Han population. Odds ratio (OR) and 95% confidence intervals (CIs) were calculated by logistic regression adjusted for age and gender in multiple genetic models.

Results

In stratified analyses by gender, three (rs1064607, rs3796283 and rs2378456) of LPP gene were associated with a significant

SUBMITTER: Yan S 

PROVIDER: S-EPMC6325744 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature