Serum 25-hydroxyvitamin D₃ is associated with advanced glycation end products (AGEs) measured as skin autofluorescence: The Rotterdam Study.

ABSTRACT: Advanced glycation end products (AGEs) accumulate in tissues with aging and may influence age-related diseases. They can be estimated non-invasively by skin autofluorescence (SAF) using the AGE Reader™. Serum 25-hydroxyvitamin D₃ (25(OH)D₃) may inhibit AGEs accumulation through anti-oxidative and anti-inflammatory properties but evidence in humans is scarce. The objective was to investigate the association between serum 25(OH)D₃ and SAF in the population-based cohort study. Serum 25(OH)D₃ and other covariates were measured at baseline. SAF was measured on average 11.5 years later. Known risk factors for AGE accumulation such as higher age, BMI, and coffee intake, male sex, smoking, diabetes, and decreased renal function were measured at baseline.

SUBMITTER: Chen J 

PROVIDER: S-EPMC6325991 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature