Comparison of dexmedetomidine vs. remifentanil combined with sevoflurane during radiofrequency ablation of hepatocellular carcinoma: a randomized controlled trial.

ABSTRACT:

Background

Remifentanil is widely used for ultrasound-guided percutaneous radiofrequency ablation (RFA) of small hepatocellular carcinoma (HCC). We determined whether dexmedetomidine could be an alternative to remifentanil for RFA of HCC under general anesthesia with sevoflurane.

Methods

We prospectively randomized patients scheduled to undergo RFA for HCC to a dexmedetomidine (DEX) group or remifentanil (REMI) group (47 patients each). In the DEX group, a bolus infusion (0.4 μg kg^- 1) was started 15 min before anesthesia induction and continued at 0.2 μg kg^- 1 h^- 1 until 10 min before the end of surgery. In the REMI group, 3 μg kg^- 1 h^- 1 of remifentanil was administered from 15 min before anesthesia induction to the en

SUBMITTER: Pan J 

PROVIDER: S-EPMC6326039 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature