Use of hormone replacement therapy and risk of venous thromboembolism: nested case-control studies using the QResearch and CPRD databases.

ABSTRACT:

Objective

To assess the association between risk of venous thromboembolism and use of different types of hormone replacement therapy.

Design

Two nested case-control studies.

Setting

UK general practices contributing to the QResearch or Clinical Practice Research Datalink (CPRD) databases, and linked to hospital, mortality, and social deprivation data.

Participants

80 396 women aged 40-79 with a primary diagnosis of venous thromboembolism between 1998 and 2017, matched by age, general practice, and index date to 391 494 female controls.

Main outcome measures

Venous thromboembolism recorded on general practice, mortality, or hospital records. Odds ratios were adjusted for demographics, smoking status, alcohol consumption, comorbidities, recent medical even

SUBMITTER: Vinogradova Y 

PROVIDER: S-EPMC6326068 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature