MicroRNAs 223-3p and 93-5p in patients with chronic kidney disease before and after renal transplantation.

ABSTRACT: Chronic kidney disease (CKD) is associated with a multifactorial dysregulation of bone and vascular calcification and closely linked to increased cardiovascular mortality and concomitant bone disease. We aimed to investigate specific microRNA (miRNA) signatures in CKD patients to find indicators for vascular calcification and/or bone mineralization changes during CKD and after kidney transplantation (KT). A miRNA array was used to investigate serum miRNA profiles in CKD patients, then selected miRNAs were quantified in a validation cohort comprising 73 patients in CKD stages 3 to 5, 67 CKD patients after KT, and 36 healthy controls. A spectrum of biochemical parameters including markers for kidney function, inflammation, glucose, and mineral metabolism was determined. The relative expressi

SUBMITTER: Ulbing M 

PROVIDER: S-EPMC6326349 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature