Sustained virological response and metabolic risk factors are associated with mortality in patients with chronic hepatitis C.

ABSTRACT:

Background and aim

Previous studies have reported that sustained virological response (SVR) to interferon-based treatment reduces the risk of mortality in chronic hepatitis C (CHC) patients, mainly in cirrhotic patients. A population-based study reported that metabolic risk factors increase the risk of mortality in CHC patients. We aim to investigate the association between SVR, metabolic risk factors and mortality in CHC patients with and without advanced fibrosis.

Methods

We collected data from 1452 CHC patients who underwent interferon-based therapy. All patients underwent liver biopsy prior to therapy. Mild fibrosis was defined as a modified Knodell score of 0-2, while advanced fibrosis was defined as a score of 3-4.

Results

1452 patients were followed up for a me

SUBMITTER: Yen YH 

PROVIDER: S-EPMC6326462 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature