An altered cytotoxic program of CD8+ T-cells in HIV-infected patients despite HAART-induced viral suppression.

ABSTRACT: Despite the suppression of viral replication induced by the highly active anti-retroviral therapy (HAART), an increased immune activation and inflammatory state persists in HIV-infected patients, contributing to lower treatment response and immune reconstitution, and development of non-AIDS conditions. The chronic activation and inflammation affect the functionality and differentiation of CD8+ T-cells, particularly reducing their cytotoxic capacity, which is critical in the control of HIV replication. Although previous studies have shown that HAART induce a partial immune reconstitution, its effect on CD8+ T-cells cytotoxic function, as well as its relationship with the inflammatory state, is yet to be defined. Here, we characterized the functional profile of polyclonal and HIV-specific CD

SUBMITTER: Perdomo-Celis F 

PROVIDER: S-EPMC6326488 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature