Accurate, robust and harmonized implementation of morpho-functional imaging in treatment planning for personalized radiotherapy.

ABSTRACT: In this work we present a methodology able to use harmonized PET/CT imaging in dose painting by number (DPBN) approach by means of a robust and accurate treatment planning system. Image processing and treatment planning were performed by using a Matlab-based platform, called CARMEN, in which a full Monte Carlo simulation is included. Linear programming formulation was developed for a voxel-by-voxel robust optimization and a specific direct aperture optimization was designed for an efficient adaptive radiotherapy implementation. DPBN approach with our methodology was tested to reduce the uncertainties associated with both, the absolute value and the relative value of the information in the functional image. For the same H&N case, a single robust treatment was planned for dose prescription m

SUBMITTER: Jimenez-Ortega E 

PROVIDER: S-EPMC6326505 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature