Pan- and core- gene association networks: Integrative approaches to understanding biological regulation.

ABSTRACT: The rapid increase in transcriptome data provides an opportunity to access the complex regulatory mechanisms in cellular systems through gene association network (GAN). Nonetheless, GANs derived from single datasets generally allow us to envisage only one side of the regulatory network, even under the particular condition of study. The circumstance is well demonstrated by inconsistent GANs of individual datasets proposed for similar experimental conditions, which always leads to ambiguous interpretation. Here, pan- and core-gene association networks (pan- and core-GANs), analogous to the pan- and core-genome concepts, are proposed to increase the power of inference through the integration of multiple, diverse datasets. The core-GAN represents the consensus associations of genes that were i

SUBMITTER: Wirojsirasak W 

PROVIDER: S-EPMC6326509 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature