Regional variations in serotype distribution and vaccination status in children under six years of age with invasive pneumococcal disease in Germany.

ABSTRACT:

Overview

The protective effect of infant pneumococcal conjugate vaccine (PCV) recommendation can be seen in Germany as a whole and in smaller regional groups. Comparisons between population-normalized geographic regions of Germany show different serotype distributions after program implementation, particularly in non-vaccine serotypes. The prior distinct differences in serotype distribution in children between the former East and former West German federal states have vanished. Children under six remain a vulnerable group, but the occurrence of vaccine-type (VT) invasive pneumococcal disease (IPD) in children correctly vaccinated (using a three-dose primary series plus one booster dose) with PCV13 was low (9 out of 374 cases, 2.4%). However, only 18.4% of children in Germany with I

SUBMITTER: Perniciaro S 

PROVIDER: S-EPMC6326516 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature