Central-to-Helical-to-Axial-to-Central Transfer of Chirality with a Photoresponsive Catalyst.

ABSTRACT: Recent advances in molecular design have displayed striking examples of dynamic chirality transfer between various elements of chirality, e.g., from central to either helical or axial chirality and vice versa. While considerable progress in atroposelective synthesis has been made, it is intriguing to design chiral molecular switches able to provide selective and dynamic control of axial chirality with an external stimulus to modulate stereochemical functions. Here, we report the synthesis and characterization of a photoresponsive bis(2-phenol)-substituted molecular switch 1. The unique design exhibits a dynamic hybrid central-helical-axial transfer of chirality. The change of preferential axial chirality in the biaryl motif is coupled to the reversible switching of helicity of the overcrow

SUBMITTER: Pizzolato SF 

PROVIDER: S-EPMC6326533 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature