SNCA overexpression disturbs hippocampal gene expression trajectories in midlife.

ABSTRACT: Synucleinopathies like Parkinson's disease and dementia with Lewy bodies originate from a complex and still largely enigmatic interplay of genetic predisposition, age, and environmental factors. While progressively declining motor functions hallmark late-life symptoms, first signs of the disease often surface already decades earlier during midlife. To better understand early disease stages with respect to the genetic, temporal, and environmental dimension, we interrogated hippocampal transcriptome data obtained during midlife for a mouse model overexpressing human SNCA, a pivotal gene in synucleinopathies, under different environments. To relate differentially expressed genes to human, we integrated expression signatures for aging and Parkinson's disease. We identified two distincti

SUBMITTER: Hentrich T 

PROVIDER: S-EPMC6326667 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature