Reduced production of laminin by hepatic stellate cells contributes to impairment in oval cell response to liver injury in aged mice.

ABSTRACT: Aged liver is usually impaired in response to hepatic injury. Tissue-specific stem cells participate in the repair of tissue injury. However, how oval cells (OCs) respond to injury and how the process is regulated by tissue microenvironment in aged mice have not been fully understood. In this study, taking advantage of well-established murine OC activation model, we demonstrated that OCs were less activated upon injury in aged mice and the impairment was mainly attributed to dysfunction in their niche. Through analyzing global gene expression, we found that the genes differentially expressed in damaged young and aged mouse liver tissues were predominantly those required for the formation and remodeling of extracellular matrix. As one of the most important extracellular matrix components in

SUBMITTER: Qian L 

PROVIDER: S-EPMC6326669 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature