Higher gene expression stability during aging in long-lived giant mole-rats than in short-lived rats.

ABSTRACT: Many aging-associated physiological changes are known to occur in short- and long-lived species with different trajectories. Emerging evidence suggests that numerous life history trait differences between species are based on interspecies variations in gene expression. Little information is available, however, about differences in transcriptome changes during aging between mammals with diverging lifespans. For this reason, we studied the transcriptomes of five tissue types and two age cohorts of two similarly sized rodent species with very different lifespans: laboratory rats (Rattus norvegicus) and giant mole-rats (Fukomys mechowii), with maximum lifespans of 3.8 and more than 20 years, respectively. Our findings show that giant mole-rats exhibit higher gene expression stabi

SUBMITTER: Sahm A 

PROVIDER: S-EPMC6326690 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature