Slow Delayed Rectifier Current Protects Ventricular Myocytes From Arrhythmic Dynamics Across Multiple Species: A Computational Study.

ABSTRACT:

Background

The slow and rapid delayed rectifier K⁺ currents (I_Ks and I_Kr, respectively) are responsible for repolarizing the ventricular action potential (AP) and preventing abnormally long APs that may lead to arrhythmias. Although differences in biophysical properties of the 2 currents have been carefully documented, the respective physiological roles of I_Kr and I_Ks are less established. In this study, we sought to understand the individual roles of these currents and quantify how effectively each stabilizes the AP and protects cells against arrhythmias across multiple species.

Methods

We compared 10 mathematical models describing ventricular myocytes from human, rabbit, dog, and guinea pig. We examined variability wit

SUBMITTER: Varshneya M 

PROVIDER: S-EPMC6326778 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature