Ribose-Map: a bioinformatics toolkit to map ribonucleotides embedded in genomic DNA.

ABSTRACT: Recent advances in high-throughput sequencing techniques have made it possible to tag ribonucleoside monophosphates (rNMPs) embedded in genomic DNA for sequencing. rNMP sequencing experiments generate large, complex datasets that require efficient, scalable software that can accurately map embedded rNMPs independently of the particular sequencing technique used. Current computational pipelines designed to map rNMPs embedded in genomic DNA are customized for data generated using only one type of rNMP sequencing technique. To standardize the processing and analysis of rNMP sequencing experiments, we developed Ribose-Map. Through a series of analytical modules, Ribose-Map transforms raw sequencing data into summary datasets and publication-ready visualizations of results, allowing biologists

SUBMITTER: Gombolay AL 

PROVIDER: S-EPMC6326787 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature