Selective Androgen Receptor Modulators: Current Knowledge and Clinical Applications.

ABSTRACT:

Introduction

Selective androgen receptor modulators (SARMs) differentially bind to androgen receptors depending on each SARM's chemical structure. As a result, SARMs result in anabolic cellular activity while avoiding many of the side effects of currently available anabolic steroids. SARMs have been studied in the treatment of breast cancer and cachexia and have also been used as performance-enhancing agents. Here, we evaluate and summarize the current literature on SARMs.

Aim

To present the background, mechanisms, current and potential clinical applications, as well as risks and benefits of SARMs.

Methods

A literature review was performed in MEDLINE using the terms selective androgen receptor modulator, hypogonadism, cachexia, breast cancer, benign prostatic hyperpla

SUBMITTER: Solomon ZJ 

PROVIDER: S-EPMC6326857 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature