Reversing Behavioral, Neuroanatomical, and Germline Influences of Intergenerational Stress.

ABSTRACT:

Background

Stressors affect populations exposed to them as well as offspring. Strategies preventing the intergenerational propagation of effects of stress would benefit public health. Olfactory cue-based fear conditioning provides a framework to address this issue.

Methods

We 1) exposed adult male mice to an odor, acetophenone (Ace) or Lyral (parental generation [F0]-Exposed), 2) trained mice to associate these odors with mild foot shocks (F0-Trained), and 3) trained mice to associate these odors with mild foot shocks and then extinguished their fear toward these odors with odor-only presentations (F0-Extinguished). We then examined sensitivity of future generation (F1) offspring to these odors, expression of M71 odorant (Ace-responsive) and MOR23 odorant (Lyral-responsive)

SUBMITTER: Aoued HS 

PROVIDER: S-EPMC6326876 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature