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Anti-prion Protein Antibody 6D11 Restores Cellular Proteostasis of Prion Protein Through Disrupting Recycling Propagation of PrP^Sc and Targeting PrP^Sc for Lysosomal Degradation.

ABSTRACT: PrP^Sc is an infectious and disease-specific conformer of the prion protein, which accumulation in the CNS underlies the pathology of prion diseases. PrP^Sc replicates by binding to the cellular conformer of the prion protein (PrP^C) expressed by host cells and rendering its secondary structure a likeness of itself. PrP^C is a plasma membrane anchored protein, which constitutively recirculates between the cell surface and the endocytic compartment. Since PrP^Sc engages PrP^C along this trafficking pathway, its replication process is often referred to as "recycling propagation." Certain monoclonal antibodies (mAbs) directed against prion protein can abrogate the presence of PrP^Sc from prion-infected cells. However, the p

SUBMITTER: Pankiewicz JE

PROVIDER: S-EPMC6326903 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Dataset Information

Anti-prion Protein Antibody 6D11 Restores Cellular Proteostasis of Prion Protein Through Disrupting Recycling Propagation of PrP^Sc and Targeting PrP^Sc for Lysosomal Degradation.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Anti-prion Protein Antibody 6D11 Restores Cellular Proteostasis of Prion Protein Through Disrupting Recycling Propagation of PrPSc and Targeting PrPSc for Lysosomal Degradation.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Anti-prion Protein Antibody 6D11 Restores Cellular Proteostasis of Prion Protein Through Disrupting Recycling Propagation of PrP^Sc and Targeting PrP^Sc for Lysosomal Degradation.