Microbatch under-oil salt screening of organic cations: single-crystal growth of active pharmaceutical ingredients.

ABSTRACT: Multicomponent solid forms of active pharmaceutical ingredients represent a modern method of tuning their physicochemical properties. Typically, salts are the most commonly used multicomponent solid form in the pharmaceutical industry. More than 38% are formulated as organic cations. Salt screening is an essential but demanding step when identifying the most appropriate formulation. The microbatch under-oil crystallization technique of proteins has been combined with the previously developed high-throughput vapour-diffusion screening for use as a novel method of primary salt screening of organic cations. The procedure allows the set up of about 100 crystallization experiments per 30 min. This requires between 17 and 564 mg of screened cationic active pharmaceutical ingredients, which were

SUBMITTER: Babor M 

PROVIDER: S-EPMC6327184 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature