Targeted Analysis of Serum Proteins Encoded at Known Inflammatory Bowel Disease Risk Loci.

ABSTRACT:

Background

Few studies have investigated the blood proteome of inflammatory bowel disease (IBD). We characterized the serum abundance of proteins encoded at 163 known IBD risk loci and tested these proteins for their biomarker discovery potential.

Methods

Based on the Human Protein Atlas (HPA) antibody availability, 218 proteins from genes mapping at 163 IBD risk loci were selected. Targeted serum protein profiles from 49 Crohn's disease (CD) patients, 51 ulcerative colitis (UC) patients, and 50 sex- and age-matched healthy individuals were obtained using multiplexed antibody suspension bead array assays. Differences in relative serum abundance levels between disease groups and controls were examined. Replication was attempted for CD-UC comparisons (including disease subtype

SUBMITTER: Drobin K 

PROVIDER: S-EPMC6327232 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature