Mutual Regulation of TLR/NLR and CEACAM1 in the Intestinal Microvasculature: Implications for IBD Pathogenesis and Therapy.

ABSTRACT:

Background

Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) displays multiple activities, among which pathogen binding and angiogenesis are particularly prominent. These same functions are also exerted by Toll- and NOD-like receptors (TLRs and NLRs), which are critical mediators of innate immune responses. We investigated whether a functional inter-relationship exists between CEACAM1 and TLRs and NLRs and its potential impact on induction of intestinal angiogenesis.

Methods

This hypothesis was tested using human intestinal microvascular endothelial cells, a unique cell population exposed to microbial products under physiological and pathological conditions.

Results

The results show that activation of TLR2/4, TLR4, NOD1, and NOD2 by specific bacteria

SUBMITTER: Schirbel A 

PROVIDER: S-EPMC6327233 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature