National trends in contralateral prophylactic mastectomy in women with locally advanced breast cancer.

ABSTRACT:

Background and objectives

Women with unilateral early-stage breast cancer are increasingly choosing contralateral prophylactic mastectomy (CPM) despite the absence of survival benefits and increased risk of surgical complications. Data are lacking on whether this trend extends to women with clinically locally advanced nonmetastatic (cT4M0) cancer. This study aims to estimate national CPM trends in women with unilateral cT4M0 breast cancer.

Methods

Women aged ≥ 18 years, who underwent mastectomy during 2004 to 2014 for unilateral cT4M0 breast cancer were identified using the National Cancer Database and grouped as all locally advanced (T4), chest wall invasion, skin nodule/ulceration, or both (T4abc), and inflammatory (T4d) cancer. Poisson regression for trends and logistic m

SUBMITTER: Panchal H 

PROVIDER: S-EPMC6327316 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature