Population and breast cancer patients' analysis reveals the diversity of genomic variation of the BRCA genes in the Mexican population.

ABSTRACT: Interpretation of variants of unknown significance (VUS) in genetic tests is complicated in ethnically diverse populations, given the lack of information regarding the common spectrum of genetic variation in clinically relevant genes. Public availability of data obtained from high-throughput genotyping and/or exome massive parallel sequencing (MPS)-based projects from several thousands of outbred samples might become useful tools to evaluate the pathogenicity of a VUS, based on its frequency in different populations. In the case of the Mexican and other Latino populations, several thousands of samples have been genotyped or sequenced during the last few years as part of different efforts to identify common variants associated to common diseases. In this report, we analyzed Mexican populati

SUBMITTER: Fernandez-Lopez JC 

PROVIDER: S-EPMC6327376 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature