Regional outbreak of community-associated methicillin-resistant Staphylococcus aureus ST834 in Japanese children.

ABSTRACT:

Background

Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection has recently become a challenging problem worldwide and in Japan. We experienced 10 pediatric patients infected with CA-MRSA and hospitalized from 2011 to 2014 in a tertiary care hospital in Saitama, Japan, and assessed the characteristic of the strains using a whole genome sequencing (WGS)-based approach.

Methods

CA-MRSA strains isolated from infected patients who required hospitalization for treatment were evaluated in this study. Antimicrobial susceptibility tests, molecular typing by PCR and pulse-field gel electrophoresis (PFGE) were performed to characterize MRSA strains. WGS was performed for detailed genetic analysis.

Results

A total of 582 MRSA strains (35.2%) were

SUBMITTER: Uehara Y 

PROVIDER: S-EPMC6327381 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature