Association between changes in gene signatures expression and disease activity among patients with systemic lupus erythematosus.

ABSTRACT:

Background

We assessed the stability of BAFF, interferon, plasma cell and LDG neutrophil gene expression signatures over time, and whether changes in expression coincided with changes in SLE disease activity.

Methods

Two hundred forty-three patients with SLE were evaluated for disease activity, serological parameters and peripheral blood gene signatures in clinic visits (2 or more per patient) that occurred between 2009 and 2012. Levels of the BAFF gene transcript, plasma cell signature, Interferon (IFN) signature and the low density granulocytes (LDG)-associated neutrophil gene signature were assessed in PAX-gene-preserved peripheral blood by global microarray. The stability of repeated measures of gene expression was quantified using intra-class correlation coefficients. S

SUBMITTER: Petri M 

PROVIDER: S-EPMC6327466 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature