Characterization of HicAB toxin-antitoxin module of Sinorhizobium meliloti.

ABSTRACT:

Background

Toxin-antitoxin (TA) systems are little genetic units generally composed of two genes encoding antitoxin and toxin. These systems are known to be involved in many functions that can lead to growth arrest and cell death. Among the different types of TA systems, the type II gathers together systems where the antitoxin directly binds and inhibits the toxin. Among these type II TA systems, the HicAB module is widely distributed in free-living Bacteria and Archaea and the toxin HicA functions via RNA binding and cleavage. The genome of the symbiotic Sinorhizobium meliloti encodes numerous TA systems and only a few of them are functional. Among the predicted TA systems, there is one homologous to HicAB modules.

Results

In this study, we characterize the HicAB toxin-anti

SUBMITTER: Thomet M 

PROVIDER: S-EPMC6327479 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature