CoMetGeNe: mining conserved neighborhood patterns in metabolic and genomic contexts.

ABSTRACT:

Background

In systems biology, there is an acute need for integrative approaches in heterogeneous network mining in order to exploit the continuous flux of genomic data. Simultaneous analysis of the metabolic pathways and genomic context of a given species leads to the identification of patterns consisting in reaction chains catalyzed by products of neighboring genes. Similar such patterns across several species can reveal their mode of conservation throughout the tree of life.

Results

We present CoMetGeNe (COnserved METabolic and GEnomic NEighborhoods), a novel method that identifies metabolic and genomic patterns consisting in maximal trails of reactions being catalyzed by products of neighboring genes. Patterns determined by CoMetGeNe in one species are subsequently emplo

SUBMITTER: Zaharia A 

PROVIDER: S-EPMC6327494 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature