Adaption to glucose limitation is modulated by the pleotropic regulator CcpA, independent of selection pressure strength.

ABSTRACT:

Background

A central theme in (micro)biology is understanding the molecular basis of fitness i.e. which strategies are successful under which conditions; how do organisms implement such strategies at the molecular level; and which constraints shape the trade-offs between alternative strategies. Highly standardized microbial laboratory evolution experiments are ideally suited to approach these questions. For example, prolonged chemostats provide a constant environment in which the growth rate can be set, and the adaptive process of the organism to such environment can be subsequently characterized.

Results

We performed parallel laboratory evolution of Lactococcus lactis in chemostats varying the quantitative value of the selective pressure by imposing two different growth rat

SUBMITTER: Price CE 

PROVIDER: S-EPMC6327505 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature