Expression of Progenitor Cell Markers in the Glial-Like Cells of Epiretinal Membranes of Different Origins.

ABSTRACT:

Purpose

To investigate the expression of progenitor cell markers (Sox2, Nestin, and Pax2) in idiopathic epiretinal membranes (iERMs) and nonidiopathic epiretinal membranes (niERMs) in relation to glial cell marker expression.

Methods

ERMs were obtained from patients with iERMs and niERMs of different origins: proliferative diabetic retinopathy (PDR), proliferative vitreoretinopathy (PVR), and uveitis. The membranes were studied by flat-mount or sectional immunohistochemistry for expression of progenitor cell markers as well as glial (GFAP) and proliferation (Ki-67) markers.

Results

Cells in the ERMs express strong GFAP, with strong Pax2 expression in the cell nuclei. Some of the GFAP-positive glial cells in all epiretinal membrane types colocalized with Sox2, Pax2, an

SUBMITTER: Yan X 

PROVIDER: S-EPMC6327511 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature