Autism spectrum disorders, endocrine disrupting compounds, and heavy metals in amniotic fluid: a case-control study.

ABSTRACT:

Background

Evidence has indicated that some non-inherited factors such as exposure to environmental pollutants are associated with neurodevelopment disorders like autism spectrum disorder (ASD). Studies report that endocrine disrupting compounds (EDCs), including polychlorinated biphenyls, organochlorine pesticides, perfluoroalkyl substances (PFAS), and some metals, have adverse effects on the fetal neurodevelopment. The aim of this study was to measure the amniotic fluid (AF) levels of EDCs and metals as well as the receptor transactivities induced by AF and investigate the possible link between prenatal exposure to EDCs and heavy metals and ASD risk.

Methods

In this case-control study, we included AF samples of 75 ASD cases and 135 frequency-matched controls and measured t

SUBMITTER: Long M 

PROVIDER: S-EPMC6327542 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature