A prospective observational study of iron isomaltoside in haemodialysis patients with chronic kidney disease treated for iron deficiency (DINO).

ABSTRACT:

Background

Iron deficiency is frequent in haemodialysis (HD) patients with chronic kidney disease (CKD), and intravenous iron is an established therapy for these patients. This study assessed treatment routine, effectiveness, and safety of iron isomaltoside (IIM) 5% (Diafer®) in a HD cohort.

Methods

This prospective observational study included 198 HD patients converted from iron sucrose (IS) and treated with IIM according to product label and clinical routine. Data for IIM were compared to historic data for IS in 3-month intervals. The primary endpoint was to show non-inferiority for IIM versus IS in haemoglobin (Hb) maintenance.

Results

Most patients (> 60%) followed a fixed low-dose iron treatment protocol. Three minutes were required for preparation and administra

SUBMITTER: Mikhail AI 

PROVIDER: S-EPMC6327585 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature