Interactions between serum urate-associated genetic variants and sex on gout risk: analysis of the UK Biobank.

ABSTRACT:

Background

Sex-specific differences in the effect of genetic variants on serum urate levels have been described. The aim of this study was to systematically examine whether serum urate-associated genetic variants differ in their influence on gout risk in men and women.

Methods

This research was conducted using the UK Biobank Resource. Thirty single nucleotide polymorphisms (SNPs) associated with serum urate were tested for their association with gout in men and women of European ancestry, aged 40-69 years. Gene-sex interactions for gout risk were analysed using an interaction analysis in logistic regression models.

Results

Gout was present in 6768 (4.1%) men and 574 (0.3%) women, with an odds ratio (95% confidence interval) for men 13.42 (12.32-14.62) compared with wo

SUBMITTER: Narang RK 

PROVIDER: S-EPMC6327586 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature